Is surgery for proliferative vitreoretinopathy justifiable?

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Outcomes of Surgery in Proliferative Vitreoretinopathy.

AIM To present the anatomical and functional outcomes of surgery in cases of rhegmatogenous retinal detachment complicated (at presentation) by proliferative vitreoretinopathy (PVR). MATERIAL AND METHODS Retrospective study of the cases operated upon by a single surgeon between October 2012 and September 2014. RESULTS A total of 49 eyes of 49 patients had PVR at presentation (12 cases with ...

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Proliferative vitreoretinopathy.

PURPOSE. The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healing conditions. The matrix metalloproteinases (MMPs) are a family of enzymes that degrade and remodel the extracellular matrix and, thus, play a central role in the wound-healing process. Proliferative vitreore...

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Apoptosis in proliferative vitreoretinopathy.

PURPOSE To study the involvement of apoptosis using different apoptosis markers in PVR pathogenesis. METHODS The presence of mRNA coding for Fas, Fas ligand (FasL), and TNF-related apoptosis inducing ligand (TRAIL) was investigated in vitreous samples from 46 consecutive patients-25 with PVR, 11 with retinal detachment (RD) not complicated by PVR, and 10 with macular hole (MH)-using RT-PCR. F...

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Keratinocyte transglutaminase in proliferative vitreoretinopathy.

PURPOSE Proliferative vitreoretinopathy (PVR) is an excessive wound-healing process and the major complication in rhegmatogenous retinal detachment. The present study was designed to investigate the expression of keratinocyte transglutaminase (kTgase) in PVR membranes and retinal pigment epithelial (RPE) cells and to evaluate its expression in response to growth factors known to be increased in...

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Intravitreal methotrexate infusion for proliferative vitreoretinopathy

PURPOSE The purpose of this study was to evaluate intravitreal methotrexate infusion (IMI) during pars plana vitrectomy (PPV) for retinal detachment in patients with high risk for the development of proliferative vitreoretinopathy (PVR). METHODS Patients presenting with severe recurrent PVR with tractional retinal detachment and/or a history of severe ocular inflammation were treated with IMI...

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ژورنال

عنوان ژورنال: Eye

سال: 1994

ISSN: 0950-222X,1476-5454

DOI: 10.1038/eye.1994.14